Up on

could you pls kindly tell me what is the meaning of "up on"? thanks a lot!

Do you mean like this?

ARTIST: The Band
TITLE: Up on Cripple Creek
Lyrics and Chords

When I get off of this mountain
You know where I want to go
Straight down the Mississippi river
To the Gulf of Mexico

To Lake Charles, Louisiana
Little Bessie, girl that I once knew
And she told me just to come on by
If there's anything she could do

{Refrain}
Up on Cripple Creek she sends me
If I spring a leak she mends me
I don't have to speak she defends me
A drunkard's dream if I ever did see one

In British English there's a phrase "well up on", meaning "knowledgeable in" (e.g. "I'm not well up on 1970s pop music").