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Balls refers to testicles. But you probably knew that. It's not about pleasure -- it's more about status. I would say that busting someone's balls is to humiliate the person, take away his or her power or standing. Emasculate him (or her). Anyone have a better explanation?

And sometimes doesn't it mean hassle someone, give him or her a hard time, the "run around"?

Ok, thanks. the next portion.

"- He came to see you the other day right before he was tagged. What did you talk about?

- The Mets. John doesn't think they have a deep enough pitching roster this year, and I'm inclined to."

I understand he meant baseball team "New York Mets", right?
But does "they have a deep enough pitching roster this year" means "they lack of pitching players" or "this pitching players aren't good enough"?
And